教师
澳门真人官网赌场的教师力求在专业上有所作为, 在学业上, 在学生的精神生活中. 澳门真人官网赌场的教授有着广泛的经验和背景. Their primary motivation is to be in the classroom with their students or in a lab working on real-world projects. 学生 are encouraged to visit professors in their offices or even contact them at home. 教师 members are ready to be friends and mentors and to build relationships that students will value for a lifetime.
教育
- 德克萨斯大学博士，1992年
教学领域
普通生物学, 期刊俱乐部:癌症生物学, 细胞生物学III:基因组学和调控, 分子生物学技术和高级微生物学
研究/利益
Professor Lindsey explains his interests as quoted: "The transformation of a fertilized egg to a complex multicellular organism depends on a variety of mechanisms that control cell-cell communication and changes in gene expression. The selective destruction of specific proteins is one of the important mechanisms that control this developmental process. Many proteins are selectively degraded by the ubiquitin-dependent proteolytic pathway. 在这个路径中, linkage of a protein to ubiquitin targets the protein for degradation by the proteasome. Defects in this pathway have been implicated in a wide range of human disorders including tumor formation and neurodegenerative diseases.
We are interested in understanding the role of ubiquitin-dependent proteolytic pathways in multicellular development. 澳门真人官网赌场使用社交变形虫 盘基网柄菌discoideum 作为一个模型系统. It is a simple and elegant system to study fundamental developmental processes that are used by higher systems including growth-to-differentiation transitions, 细胞定向运动, 程控的决心, 形成具有特定大小和形状的结构.
盘基网柄菌 normally exists as solitary cells that proliferate by cell division while feeding on bacteria in soil and decaying leaves. 在饥饿的压力下, these amoebae stop dividing and enter a developmental program that results in the formation of a multicellular fruiting body. The cells first aggregate into a mound which then elongates to form a slug that can migrate to a suitable location for fruiting body formation. 被指定为柄细胞的细胞, 前秆细胞, occupy the tip of the slug; the posterior region of the slug contains mostly prespore cells. 最终, coordinated cell movements and additional differentiation events result in a fruiting body consisting of a mass of spore cells supported on a column of stalk cells.
We have identified two enzymes that appear to function in ubiquitin-dependent proteolytic pathways and are required for 盘基网柄菌 development: UbpA and RbrA. UbpA是酵母Ubp14和人异肽酶T的功能同源物, enzymes which appear to function in the disassembly of free ubiquitin chains following their use as tags for protein degradation. It is likely that these enzymes facilitate ubiquitin dependent proteolysis by preventing free ubiquitin chains from competing for substrate binding sites on the proteasome. Control of cellular ubiquitin chain levels by UbpA may provide a mechanism for modulating the rates of protein degradation by the proteasome during changing developmental conditions. We are currently investigating the role of UbpA at the growth-development transition by analyzing defects found in ubpA-deficient cells. Results from this work may elucidate 分子 mechanisms that underlie the conversion of stem cells to differentiating cells.
RbrA is a putative ubiquitin ligase that is required for cell-type proportioning and pattern formation. RbrA-deficient cells form slugs that are unable to phototax or develop into fruiting bodies. RbrA is highly similar to ariadne-like ubiquitin ligases, which are members of the RBR family. RBR家族成员广泛存在于真核生物中，包括帕金, 一种与帕金森病有关的基因. 描绘rbra依赖通路, 澳门真人官网赌场使用基因, 分子, 以及生物化学方法来识别与RbrA相互作用的蛋白质."
教育
- PhD University of California, Santa Barbara, 1987; Aquatic and Population Biology
教学领域
普通生物学, 植物生物学, 湖沼学, 生态生理学, 海洋生物学, 海洋生态学与海洋无脊椎动物
研究/利益
Professor Cowles is interested in questions that involve animals' survival in the sea. 他目前参与的项目包括:
- 是什么导致了新月湖的藻华, 这是华盛顿州一个美丽的超营养化湖泊
- 如何 Hemisquilla californiensis, an active burrow-dwelling stomatopod, survives under low oxygen conditions in its burrow
- 的眼睛和视野 H. californiensis，以及它所响应的颜色
- 污染对海洋无脊椎动物基因库的影响
- 如何 closely related are individuals of the same deep-sea species which are separated by thousands of miles of ocean?
- 一些深海中水甲壳类动物的游泳能量学和代谢
- 垂直迁移
其他研究兴趣包括生态生理学, 海洋生物学, 海洋物种生理, 深海和近岸都有.
教育
- PhD Purdue University, 2006; Biomedical Engineering
- BS Montana State University, 2001; Chemical Engineering, Bio focus
教学领域
生物材料，组织工程，生物反应器
经验
- 沃拉沃拉大学工程学院，2017-至今
- 沃拉沃拉大学生物系，2011-2017
- 常青藤科技社区学院生物技术主席，2008-2011
- Nanovis，首席科学官，2007年
- 组织工程应用生物材料研究
爱好
Bible studies, prison ministry, gardening, skiing, biking, running, enjoying animals and nature
其他
专业协会
- 生物材料学会(SFB)
- 国际组织工程与再生医学学会(TERMIS)
- 生物医学工程学会(BMES)
房间
陈顺阁257
教育
- PhD University of Colorado, Boulder, 1990; Environmental, Population, Organismic Biology
课程
普通生物学, biostatistics, scientific diving and natural history of vertebrates
研究/利益
内斯特勒教授的研究主要集中在对海参的研究上. He is specifically interested in answering the following questions through research:
- “海参真的很重要吗? 它们在海洋环境中有什么特殊的功能吗? 谁在乎他们会不会被吃掉然后消失?"
- “为什么有些海参在冬天会失去所有的内脏?, 一两个月后才重新长出来?"
教育
- 华盛顿州立大学博士，2013年
课程
生物研究, 细胞生物学I:结构与生物能量学, 生物计算、生物信息学和动物生理学
研究/利益
- Research interests include 生态生理学 and behavioral ecology of marine invertebrates, 尤其是头足类动物.
- His current research is focused around the idea that all living things must bring to bear specific physiological adaptations to survive and thrive in the environments in which they find themselves. 他对头足类动物的生理机制特别感兴趣, 哪个和鼻涕虫的相似, 蜗牛和蛤蜊, 使这群海洋无脊椎动物活跃起来, 与脊椎动物竞争的移动掠食者. 他对改编也很感兴趣, 从行为和生理到动态, 改变环境, 比如热液喷口.
教育
洛马林达大学牙科学院，2000年.
Residency in Pediatric Dentistry, Loma Linda University School of Dentistry, 2002.
教学领域
解剖学 & 生理学
经验
私人执业，儿科牙医，2002-2022
爱好
音乐、水肺潜水、骑自行车、滑雪、折叠、美食(尤其是咖啡)